Dihydrotestosterone (DHT) is a potent androgen hormone formed from testosterone by the enzyme 5-alpha reductase. It is approximately 2–3 times more biologically active than testosterone and binds to androgen receptors with much greater affinity. DHT plays a critical role in the development of male sexual characteristics during foetal development and at puberty.
In adults, DHT is most strongly associated with the prostate gland and hair follicles. Elevated DHT is a primary driver of benign prostatic hyperplasia (BPH) and male pattern baldness (androgenetic alopecia). In women, excess DHT can contribute to female pattern hair loss, acne, and hirsutism. Testing DHT is relevant when investigating these conditions or assessing the effects of 5-alpha reductase inhibitors such as finasteride.
FAQs
What does DHEAS tell me that testosterone does not?
DHEAS reflects adrenal androgenic activity specifically, as it is produced almost exclusively by the adrenal glands. Testosterone is produced by both the gonads and adrenals. When androgen excess is present, elevated DHEAS points to an adrenal source, while normal DHEAS with high testosterone points to an ovarian or testicular source.
Is DHEA supplementation safe?
DHEA supplements are available over the counter in Australia and are generally considered safe at recommended doses in adults with documented low levels. Side effects of excessive DHEA include acne, hair loss, and androgenic effects in women. Use should be guided by measured DHEAS levels and medical supervision.
Why is DHEAS called the youth hormone?
DHEAS peaks in young adulthood and declines steeply with age, mirroring the general trajectory of vitality and resilience. Researchers have noted that higher DHEAS in older adults is associated with better physical function, cognitive performance, and longevity, though whether this is causal or simply a marker of general health is not fully established.
Can DHEAS be tested at any time of day?
Yes. Unlike cortisol, which has a strong diurnal rhythm, DHEAS levels are relatively stable throughout the day. It can be collected at any time without the need for timed sampling.
